FOXO4-DRI Research & Studies
We track 17 published, PubMed-indexed studies for FOXO4-DRI, spanning 2017 to 2025. The research below includes 14 research articles, 3 reviews.
These summaries are for educational purposes. Research findings, particularly from preclinical studies, may not translate to human outcomes. Always consult a qualified healthcare provider before making decisions based on this information.
14
Research Articles
3
Reviews
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.
Research ArticleKong YX, Li ZS, et al.|Commun Biol|2025
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
Research ArticleBourgeois B, Spreitzer E, et al.|Nat Commun|2025
FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway.
Research ArticleHu Z, Li F, et al.|Front Bioeng Biotechnol|2025
FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells.
Research ArticleLi Y, Zhang C, et al.|Exp Gerontol|2024
Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia.
Research ArticleJing X, Jia S, et al.|Am J Respir Cell Mol Biol|2024
Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.
Research ArticleBorn E, Lipskaia L, et al.|Circulation|2023
FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice.
Research ArticleLiu Y, Hou Q, et al.|Naunyn Schmiedebergs Arch Pharmacol|2023
Bioinformatics procedure for investigating senolytic (anti-aging) agents: A digital signal processing technique.
Research ArticleNwankwo N, Okafor I|Aging Med (Milton)|2023
FOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice through ECM-receptor interaction pathway.
Research ArticleHan X, Yuan T, et al.|J Cell Mol Med|2022
Targeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin Is a Novel Approach for Senolysis.
Research ArticleDeryabin PI, Shatrova AN, Borodkina AV|Int J Mol Sci|2022
Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes.
Research ArticleHuang Y, He Y, et al.|Front Bioeng Biotechnol|2021
Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis.
Research ArticleMeng J, Li Y, et al.|JCI Insight|2021
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
Research ArticleZhang C, Xie Y, et al.|Aging (Albany NY)|2020
Cellular senescence in the aging and diseased kidney.
ReviewValentijn FA, Falke LL, et al.|J Cell Commun Signal|2018
Cellular senescence as a therapeutic target to improve renal transplantation outcome.
Reviewvan Willigenburg H, de Keizer PLJ, de Bruin RWF|Pharmacol Res|2018
[Molecular regulative mechanisms of aging and interventional effects of Chinese herbal medicine].
ReviewLiu BH, Gu YH, et al.|Zhongguo Zhong Yao Za Zhi|2017
Rejuvenation by Therapeutic Elimination of Senescent Cells.
Research ArticleKrimpenfort P, Berns A|Cell|2017