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Dihexa Research & Studies

We track 14 published, PubMed-indexed studies for Dihexa, spanning 2013 to 2026. The research below includes 4 reviews, 7 research articles, 1 clinical trial, 2 retracteds.

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These summaries are for educational purposes. Research findings, particularly from preclinical studies, may not translate to human outcomes. Always consult a qualified healthcare provider before making decisions based on this information.
4
Reviews
7
Research Articles
1
Clinical Trial
2
Retracteds

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.

Review
Rahman OF, Lee SJ, Seeds WA|J Am Acad Orthop Surg Glob Res Rev|2026
PubMed (PMID: 41490200)DOI: 10.5435/JAAOSGlobal-D-25-00236

Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats.

Research Article
Wells RG, Azzam AF, et al.|J Huntingtons Dis|2024
PubMed (PMID: 38489193)DOI: 10.3233/JHD-231507

Athira Pharma fosgonimeton (ATH-1017/Dihexa-derivative) Phase 2/3 LIFT-AD trial failure in mild-to-moderate Alzheimer's disease (2024). Trial did not meet primary endpoints.

Clinical Trial
Athira Pharma|Company Press Release / Clinical Trial Report|2024
PubMed (PMID: NCT04491006)

Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy.

Research Article
Pan T, Wang N, et al.|Stem Cell Res Ther|2022
PubMed (PMID: 35410439)DOI: 10.1186/s13287-022-02831-1

AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.

Research Article
Sun X, Deng Y, et al.|Brain Sci|2021
PubMed (PMID: 34827486)DOI: 10.3390/brainsci11111487

Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.

Research Article
Weiss JB, Phillips CJ, et al.|Ann Med Surg (Lond)|2021
PubMed (PMID: 34703584)DOI: 10.1016/j.amsu.2021.102917

Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies.

Review
Ho JK, Nation DA|Neurosci Biobehav Rev|2018
PubMed (PMID: 29733881)DOI: 10.1016/j.neubiorev.2018.05.005

Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells.

Research Article
Mathapati S, Siller R, et al.|Curr Protoc Stem Cell Biol|2016
PubMed (PMID: 27532814)DOI: 10.1002/cpsc.13

The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease.

Review
Wright JW, Harding JW|J Alzheimers Dis|2015
PubMed (PMID: 25649658)DOI: 10.3233/JAD-142814

The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases.

Review
Wright JW, Kawas LH, Harding JW|Prog Neurobiol|2015
PubMed (PMID: 25455861)DOI: 10.1016/j.pneurobio.2014.11.004

Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure.

Research Article
Uribe PM, Kawas LH, et al.|Front Cell Neurosci|2015
PubMed (PMID: 25674052)DOI: 10.3389/fncel.2015.00003

Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells.

Research Article
Siller R, Greenhough S, et al.|Stem Cell Reports|2015
PubMed (PMID: 25937370)DOI: 10.1016/j.stemcr.2015.04.001

The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.

Retracted
Benoist CC, Kawas LH, et al.|J Pharmacol Exp Ther|2014
PubMed (PMID: 25187433)DOI: 10.1124/jpet.114.218735

Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.

Retracted
McCoy AT, Benoist CC, et al.|J Pharmacol Exp Ther|2013
PubMed (PMID: 23055539)DOI: 10.1124/jpet.112.199497
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