Dihexa
Brain peptide originally claimed to be 10 million times more potent than BDNF for forming connections. However, the foundational paper was retracted in April 2025 after confirmed data fabrication. A clinical trial also failed all endpoints. Evidence base is now significantly weakened.
Key Facts
- ClassificationPeptide — Experimental brain peptide for forming new neural connections. Limited safety data.
- Primary BenefitsBrain & Cognition (5/10) · Longevity (2/10)
- AdministrationOral, Injection
- Typical Dose10-20 mg oral or 5-10 mg subq daily. Cycle for 4-8 weeks with breaks in between. NOTE: foundational research retracted in 2025 -- consider alternatives like Cerebrolysin or Semax with stronger evidence.
- Evidence StrengthAnecdotal — 14 peer-reviewed studies referenced · Community sentiment 8/10
- Stacks Well WithSemax, Selank, NA-Semax Amidate, SS-31
- Legal StatusResearch Use Only · not prescribable in US
Quick Facts
- From price
- $50
- Type
- peptide
- Administration
- Oral, Injection
- Evidence
- anecdotal
- Studies referenced
- 14
- Community sentiment
- 8/10
- Stacks with
- 6 peptides
- Regulatory
- Research Use Only
Top benefits
Week 1–2
Rapid cognitive enhancement — improved memory formation, focus, and mental clarity. Enhanced pattern recognition. Mood brightening.
Week 3–6
Sustained nootropic effects. Improved spatial and verbal memory. Enhanced learning capacity. Neuroplasticity effects building. BDNF pathway activation.
Week 8+
Peak cognitive benefits. Long-term neuroprotective effects. However, long-term safety data is very limited — caution warranted.
Common Side Effects
Dosing
10-20 mg oral or 5-10 mg subq daily. Cycle for 4-8 weeks with breaks in between. NOTE: foundational research retracted in 2025 -- consider alternatives like Cerebrolysin or Semax with stronger evidence.
Reconstitution, storage, injection sites & timing
Benefit Profile
| Vendor | Variant | Price | |
|---|---|---|---|
| Limitless Biotech | 10mg | $52.99 | Code: PSTACK10Buy |
| Skye Peptides | 10mg | $49.99BEST | |
| Peptide Sciences ✕ Announced voluntary shutdown — stock availability may be limited or unavailable. Pricing data may be outdated. | 10mg | $59.00 | Out of stock |
Stacks Well With
Semax
Brain-boosting peptide that increases BDNF by ~1.4x at the protein level and up to 3x at mRNA level in animal studies. Promotes neurogenesis, improves cerebral blood flow. Used clinically in Russia for stroke recovery and cognitive decline.
Selank
Russian anxiolytic peptide working on GABA, serotonin, and enkephalin systems. Eases anxiety without sedation or dependence risk. Also boosts immunity. Decades of clinical use.
NA-Semax Amidate
Enhanced Semax with modifications for better absorption and potency. Stronger BDNF boost with longer-lasting cognitive benefits.
SS-31 (Elamipretide)
Engineered to target inner mitochondrial membrane via cardiolipin binding. Stabilizes cristae, improves ATP production, and reduces oxidative stress. FDA-approved for Barth syndrome (as Forzinity) — the first FDA-approved mitochondria-targeted therapy.
NAD+ (Nicotinamide Adenine Dinucleotide)
Critical molecule for cellular energy and DNA repair. Levels may drop ~50% by middle age. Activates sirtuin longevity genes and powers PARP DNA repair enzymes. Injectable form bypasses oral absorption issues.
Cerebrolysin
Brain-repair peptide blend from pig brain tissue containing natural nerve growth factors. Used for stroke and TBI recovery in 50+ countries. Strongest RCT evidence of any brain peptide.
Related 🧠 Brain & Cognition Peptides
Other peptides strong in brain & cognition
Fast-acting antidepressant and cognitive enhancer. Blocks TREK-1 channels.
N-Acetyl Selank Amidate8/10Enhanced Selank with better stability. Reduces anxiety, boosts focus and mood.
9-Me-BC (9-Methyl-β-carboline)8/10Unique dopamine-enhancing brain booster that promotes nerve growth.
Pinealon7/10Brain bioregulator that works at the gene level. Supports sleep and cognition.
Cortagen7/10Brain bioregulator targeting the cerebral cortex for sharper thinking.