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Epithalon (Epitalon) Research & Studies

We track 20 published, PubMed-indexed studies for Epithalon (Epitalon), spanning 1994 to 2026. The research below includes 9 reviews, 7 research articles, 4 clinical trials.

These summaries are for educational purposes. Research findings, particularly from preclinical studies, may not translate to human outcomes. Always consult a qualified healthcare provider before making decisions based on this information.
9
Reviews
7
Research Articles
4
Clinical Trials

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.

Review
Rahman OF, Lee SJ, Seeds WA|J Am Acad Orthop Surg Glob Res Rev|2026

Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.

Review
Araj SK, Brzezik J, et al.|Int J Mol Sci|2025

Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.

Research Article
Al-Dulaimi S, Thomas R, et al.|Biogerontology|2025

Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.

Research Article
Ullah S, Haider Z, et al.|Life Sci|2025

The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.

Research Article
Gatta M, Dovizio M, et al.|Stem Cell Rev Rep|2025

Correction: Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.

Research Article
Al-Dulaimi S, Thomas R, et al.|Biogerontology|2025

Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.

Research Article
Yue X, Liu SL, et al.|Aging (Albany NY)|2022

Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.

Research Article
Avolio F, Martinotti S, et al.|Int J Mol Sci|2022

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.

Research Article
Khavinson V, Diomede F, et al.|Molecules|2020

[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].

Review
Khavinson VKh, Kuznik BI, et al.|Adv Gerontol|2014

[Morphofunctional and molecular bases of pineal gland aging].

Review
Khavinson VKh, Lin'kova NS|Fiziol Cheloveka|2012

Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: results of 15-year follow-up.

Clinical Trial
Korkushko OV, Khavinson VKh, et al.|Bull Exp Biol Med|2011

[Characteristics of the pineal gland and thymus relationship in aging].

Review
Lin'kova NS, Poliakova VO, et al.|Adv Gerontol|2011

[Influence of peptides from pineal gland on thymus function at aging].

Review
Lin'kova NS, Poliakova VO, et al.|Adv Gerontol|2010

Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people.

Clinical Trial
Korkushko OV, Khavinson VKh, et al.|Bull Exp Biol Med|2004

Peptides of pineal gland and thymus prolong human life.

Clinical Trial
Khavinson VKh, Morozov VG|Neuro Endocrinol Lett|2003

Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.

Clinical Trial
Khavinson V, Razumovsky M, et al.|Neuro Endocrinol Lett|2002

Peptides and Ageing.

Review
Khavinson VKh|Neuro Endocrinol Lett|2002

Twenty years of study on effects of pineal peptide preparation: epithalamin in experimental gerontology and oncology.

Review
Anisimov VN, Khavinson VKh, Morozov VG|Ann N Y Acad Sci|1994

Artificial life extension. The epigenetic approach.

Review
Kloeden PE, Rössler R, Rössler OE|Ann N Y Acad Sci|1994