peptide
Epithalon (Epitalon)
moderateResearch Use OnlyInjectionOral
Longevity peptide from the pineal gland. Activates telomerase to protect DNA caps and restores melatonin production. Russian studies showed 11-16% lifespan increase in animals.
Key facts
- Classification
- Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on bovine pineal gland extract.
- Primary benefits
- Longevity (10/10) · Sleep (7/10) · Immune Support (4/10)
- Administration
- Injection, Oral
- Doses studied
- Two approaches: 3 mg oral daily on an ongoing basis, OR 5-10 mg subq daily for 10-20 days as a "pulse" done twice a year. The continuous low-dose oral route may be better for long-term DNA cap (telomere) support.
- Evidence strength
- Moderate — 20 peer-reviewed studies
- Stacks well with
- GHK-Cu, Thymalin, SS-31, NAD+
- Legal status
- Research Use Only · not prescribable in US
Quick stats
- Type
- Peptide
- Administration
- Injection, Oral
- Studies referenced
- 20
- Stacks with
- 6 peptides
- Regulatory
- Research Use Only
Scientific overview
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on bovine pineal gland extract. Primary mechanism involves telomerase (hTERT) activation, extending telomere length. An observational study in 162 elderly patients suggested reduced cardiovascular mortality over 6 years, though with significant methodological limitations. Also modulates melatonin secretion and circadian regulation.
Goal coverage · Epithalon (Epitalon)
⏳ Longevity10/10
😴 Sleep7/10
🛡️ Immune Support4/10
🧠 Brain & Cognition3/10
✨ Skin & Hair3/10
Medical oversight recommendedNot safe during pregnancy· 2 contraindications