Epithalon (Epitalon)
Longevity peptide from the pineal gland. Activates telomerase to protect DNA caps and restores melatonin production. Russian studies showed 11-16% lifespan increase in animals.
Key Facts
- ClassificationEpithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on bovine pineal gland extract.
- Primary BenefitsLongevity (10/10) · Sleep (7/10) · Immune Support (4/10)
- AdministrationInjection, Oral
- Typical DoseTwo approaches: 3 mg oral daily on an ongoing basis, OR 5-10 mg subq daily for 10-20 days as a "pulse" done twice a year. The continuous low-dose oral route may be better for long-term DNA cap (telomere) support.
- Evidence StrengthModerate — 20 peer-reviewed studies referenced · Community sentiment 8/10
- Stacks Well WithGHK-Cu, Thymalin, SS-31, NAD+
- Legal StatusResearch Use Only · not prescribable in US
Quick Facts
- From price
- $25
- Type
- peptide
- Administration
- Injection, Oral
- Evidence
- moderate
- Studies referenced
- 20
- Community sentiment
- 8/10
- Stacks with
- 6 peptides
- Regulatory
- Research Use Only
Top benefits
Week 1–2
Improved sleep onset and quality via melatonin modulation. Subtle increase in overall energy. No dramatic changes expected — mechanism is gradual.
Week 3–6
Better circadian rhythm regulation. Improved skin appearance. Telomerase activation occurring at cellular level.
Week 8+
Cumulative anti-aging effects. Improved antioxidant status. Enhanced melatonin production. Full telomere-lengthening benefits require repeated cycles over years.
Common Side Effects
Scientific Overview
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on bovine pineal gland extract. Primary mechanism involves telomerase (hTERT) activation, extending telomere length. An observational study in 162 elderly patients suggested reduced cardiovascular mortality over 6 years, though with significant methodological limitations. Also modulates melatonin secretion and circadian regulation.
Dosing
Two approaches: 3 mg oral daily on an ongoing basis, OR 5-10 mg subq daily for 10-20 days as a "pulse" done twice a year. The continuous low-dose oral route may be better for long-term DNA cap (telomere) support.
Reconstitution, storage, injection sites & timing
Benefit Profile
| Vendor | Variant | Price | |
|---|---|---|---|
| Limitless Biotech | 10mg | $34.99 | Code: PSTACK10Buy |
| Skye Peptides | 10mg | $29.99 | |
| Skye Peptides | 50mg | $99.99 | |
| Swiss Chems ⚠ FDA warning letter received late 2024 | 10mg | $32.95 | |
| Amino Asylum ⚠ Reported federal raid in 2025 | 10mg | $24.99BEST | |
| Peptide Sciences ✕ Announced voluntary shutdown — stock availability may be limited or unavailable. Pricing data may be outdated. | 10mg | $39.00 | Out of stock |
Stacks Well With
GHK-Cu (Copper Peptide)
A naturally occurring copper peptide your body already makes. Drives skin rejuvenation, wound healing, and anti-aging by boosting collagen and activating anti-aging genes.
Thymalin
Derived from the thymus gland. Restores immune function and has shown life-extending properties by reactivating the aging immune system.
SS-31 (Elamipretide)
Engineered to target inner mitochondrial membrane via cardiolipin binding. Stabilizes cristae, improves ATP production, and reduces oxidative stress. FDA-approved for Barth syndrome (as Forzinity) — the first FDA-approved mitochondria-targeted therapy.
NAD+ (Nicotinamide Adenine Dinucleotide)
Critical molecule for cellular energy and DNA repair. Levels may drop ~50% by middle age. Activates sirtuin longevity genes and powers PARP DNA repair enzymes. Injectable form bypasses oral absorption issues.
Pinealon
Three-amino-acid Khavinson bioregulator that enters cells and interacts with DNA to activate brain-protective protein production. Reduces brain cell death and enhances neuronal repair.
FOXO4-DRI
Longevity peptide that selectively triggers senescent 'zombie cells' to self-destruct while sparing healthy cells. One of the most precise senolytic tools available.
Compare
Epithalon and GHK-Cu are both studied in the context of aging, but they target entirely different aging mechanisms. Epithalon focuses on telomere maintenance at the DNA level, while GHK-Cu modulates gene expression and tissue remodeling. They represent "inside-out" approaches to anti-aging research.
FOXO4-DRI vs EpithalonFOXO4-DRI and Epithalon both target aging, but through opposing strategies. FOXO4-DRI is a senolytic -- it selectively destroys aged "zombie" cells (senescent cells) that accumulate with age. Epithalon aims to keep healthy cells functioning longer by maintaining telomere length. They represent "destroy the old" vs. "preserve the functional."
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