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GHK-Cu (Copper Peptide) Research & Studies

We track 20 published, PubMed-indexed studies for GHK-Cu (Copper Peptide), spanning 2012 to 2026. The research below includes 9 reviews, 11 research articles.

These summaries are for educational purposes. Research findings, particularly from preclinical studies, may not translate to human outcomes. Always consult a qualified healthcare provider before making decisions based on this information.
9
Reviews
11
Research Articles

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.

Review
Rahman OF, Lee SJ, Seeds WA|J Am Acad Orthop Surg Glob Res Rev|2026

Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.

Review
Mayfield CK, Bolia IK, et al.|Am J Sports Med|2026

Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective.

Review
Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR|Bioimpacts|2025

Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes?

Review
Ogórek K, Nowak K, et al.|Molecules|2025

Protective Functions of β-Alanyl-L-Histidine and Glycyl-L-Histidyl-L-Lysine Glycoconjugates and Copper in Concert.

Review
Naletova I, Rizzarelli E|Antioxidants (Basel)|2025

Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms.

Research Article
Mao S, Huang J, et al.|Front Pharmacol|2025

An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant.

Research Article
Hu D, Zhang X, et al.|Colloids Surf B Biointerfaces|2025

The glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6.

Research Article
Bian Y, Deng M, et al.|Redox Biol|2024

Novel Applications of CE-ICP-MS/MS: Monitoring of Antiaging GHK-Cu Cosmetic Component Encapsulation in Liposomes.

Research Article
Zajda J, Wadych E, et al.|Electrophoresis|2024

Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application.

Research Article
Dymek M, Olechowska K, et al.|Pharmaceutics|2023

Phenothiazine-Based Cu(II)-Selective Fluorescent Sensor: GHK-Cu Sensing Applications.

Research Article
Sahu R, Yadav S, et al.|J Org Chem|2023

Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests.

Research Article
Jiang F, Wu Y, et al.|J Cosmet Dermatol|2023

Glycyl-l-histidyl-l-lysine-Cu(2+) rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway.

Research Article
Deng M, Zhang Q, et al.|J Cachexia Sarcopenia Muscle|2023

The potential of GHK as an anti-aging peptide.

Research Article
Dou Y, Lee A, et al.|Aging Pathobiol Ther|2020

Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate.

Research Article
Bossak-Ahmad K, Wiśniewska MD, et al.|Int J Mol Sci|2020

Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways.

Research Article
Ma WH, Li M, et al.|Life Sci|2020

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.

Review
Pickart L, Margolina A|Int J Mol Sci|2018

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.

Review
Pickart L, Vasquez-Soltero JM, Margolina A|Biomed Res Int|2015

Developments in the synthesis and biological activity of glycyl-L-histydyl- L-lysine derivatives.

Review
Kukowska M, Dzierzbicka K|Curr Med Chem|2014

The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.

Review
Pickart L, Vasquez-Soltero JM, Margolina A|Oxid Med Cell Longev|2012