Skip to content
Home/Research/Semax

Semax Research & Studies

We track 20 published, PubMed-indexed studies for Semax, spanning 2006 to 2026. The research below includes 2 reviews, 17 research articles, 1 clinical trial.

View Semax details, dosing & pricing →
These summaries are for educational purposes. Research findings, particularly from preclinical studies, may not translate to human outcomes. Always consult a qualified healthcare provider before making decisions based on this information.
2
Reviews
17
Research Articles
1
Clinical Trial

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.

Review
Rahman OF, Lee SJ, Seeds WA|J Am Acad Orthop Surg Glob Res Rev|2026
PubMed (PMID: 41490200)DOI: 10.5435/JAAOSGlobal-D-25-00236

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.

Research Article
Liu R, Chen Y, et al.|Br J Pharmacol|2025
PubMed (PMID: 40692165)DOI: 10.1111/bph.70122

Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.

Research Article
Tomasello MF, Di Rosa MC, et al.|Bioinorg Chem Appl|2025
PubMed (PMID: 40496623)DOI: 10.1155/bca/4226220

The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons.

Research Article
Kolbaev SN, Sharonova IN, Skrebitsky VG|Bull Exp Biol Med|2025
PubMed (PMID: 41171324)DOI: 10.1007/s10517-025-06501-z

Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.

Research Article
Inozemtseva LS, Yatsenko KA, et al.|Eur J Pharmacol|2024
PubMed (PMID: 39442746)DOI: 10.1016/j.ejphar.2024.177068

Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.

Research Article
Sciacca MFM, Naletova I, et al.|ACS Chem Neurosci|2022
PubMed (PMID: 35080861)DOI: 10.1021/acschemneuro.1c00707

Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.

Research Article
Glazova NY, Manchenko DM, et al.|Neuropeptides|2021
PubMed (PMID: 33418449)DOI: 10.1016/j.npep.2020.102114

Brain Protein Expression Profile Confirms the Protective Effect of the ACTH((4-7))PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion.

Research Article
Sudarkina OY, Filippenkov IB, et al.|Int J Mol Sci|2021
PubMed (PMID: 34201112)DOI: 10.3390/ijms22126179

[The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain].

Research Article
Dergunova LV, Dmitrieva VG, et al.|Mol Biol (Mosk)|2021
PubMed (PMID: 34097675)DOI: 10.31857/S0026898421010043

Functional Connectomic Approach to Studying Selank and Semax Effects.

Research Article
Panikratova YR, Lebedeva IS, et al.|Dokl Biol Sci|2020
PubMed (PMID: 32342318)DOI: 10.1134/S001249662001007X

Novel Insights into the Protective Properties of ACTH((4-7))PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.

Research Article
Filippenkov IB, Stavchansky VV, et al.|Genes (Basel)|2020
PubMed (PMID: 32580520)DOI: 10.3390/genes11060681

Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress.

Research Article
Svishcheva MV, Mukhina AY, et al.|Bull Exp Biol Med|2020
PubMed (PMID: 32737723)DOI: 10.1007/s10517-020-04886-7

Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of "Social" Stress.

Research Article
Samotrueva MA, Yasenyavskaya AL, et al.|Bull Exp Biol Med|2019
PubMed (PMID: 31028579)DOI: 10.1007/s10517-019-04434-y

[The efficacy of semax in the tretament of patients at different stages of ischemic stroke].

Clinical Trial
Gusev EI, Martynov MY, et al.|Zh Nevrol Psikhiatr Im S S Korsakova|2018
PubMed (PMID: 29798983)DOI: 10.17116/jnevro20181183261-68

Effects of Semax on the Default Mode Network of the Brain.

Research Article
Lebedeva IS, Panikratova YR, et al.|Bull Exp Biol Med|2018
PubMed (PMID: 30225715)DOI: 10.1007/s10517-018-4234-3

Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.

Research Article
Medvedeva EV, Dmitrieva VG, et al.|Mol Genet Genomics|2017
PubMed (PMID: 28255762)DOI: 10.1007/s00438-017-1297-1

Semax prevents learning and memory inhibition by heavy metals.

Research Article
Inozemtsev AN, Bokieva SB, et al.|Dokl Biol Sci|2016
PubMed (PMID: 27411820)DOI: 10.1134/S0012496616030066

Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties.

Research Article
Magrì A, Tabbì G, et al.|J Inorg Biochem|2016
PubMed (PMID: 27586814)DOI: 10.1016/j.jinorgbio.2016.08.013

Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity.

Research Article
Tabbì G, Magrì A, et al.|J Inorg Biochem|2015
PubMed (PMID: 25310602)DOI: 10.1016/j.jinorgbio.2014.09.008

[Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application].

Review
Liapina LA, Pastorova VE, et al.|Izv Akad Nauk Ser Biol|2006
PubMed (PMID: 16634437)
View Semax Details← All Research