peptide
Semax
moderateResearch Use OnlyIntranasalInjection
Brain-boosting peptide that increases BDNF by ~1.4x at the protein level and up to 3x at mRNA level in animal studies. Promotes neurogenesis, improves cerebral blood flow. Used clinically in Russia for stroke recovery and cognitive decline.
Key facts
- Classification
- Semax is a synthetic ACTH(4-10) analog without corticotropic activity.
- Primary benefits
- Brain & Cognition (9/10) · Mood & Anxiety (5/10) · Injury Healing (3/10)
- Administration
- Intranasal, Injection
- Doses studied
- 300-600 mcg subq or nasal spray, 3 times a week on an empty stomach. Take it before noon. Cycle: 8-12 weeks on, 2 weeks off. Can be mixed in the same syringe with SS-31, NAD+, or Selank.
- Evidence strength
- Moderate — 20 peer-reviewed studies
- Stacks well with
- Selank, Dihexa, SS-31, NAD+
- Legal status
- Research Use Only · not prescribable in US
Quick stats
- Type
- Peptide
- Administration
- Intranasal, Injection
- Studies referenced
- 20
- Stacks with
- 6 peptides
- Regulatory
- Research Use Only
Scientific overview
Semax is a synthetic ACTH(4-10) analog without corticotropic activity. Demonstrates nootropic and neuroprotective properties through BDNF/trkB signaling, hippocampal neurogenesis, and NGF/NT-3 upregulation. Increases cerebral blood flow. Approved in Russia for stroke, cognitive disorders, and optic nerve atrophy.
Goal coverage · Semax
🧠 Brain & Cognition9/10
😌 Mood & Anxiety5/10
🩹 Injury Healing3/10
Medical oversight recommendedNot safe during pregnancy· 2 contraindications