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KPV

Research Use Only
peptideOralInjection

Three-amino-acid anti-inflammatory peptide especially effective for gut inflammation. Go-to for IBD and inflammatory gut issues. Also calms systemic inflammation.

Key Facts

  • Classification
    KPV is an α-MSH-derived tripeptide retaining anti-inflammatory properties without melanotropic activity.
  • Primary Benefits
    Gut Health (9/10) · Inflammation (9/10) · Immune Support (4/10)
  • Administration
    Oral, Injection
  • Typical Dose
    200-500 mcg oral or subq daily. Take it by mouth if you're targeting the gut specifically. Cycle for 4-8 weeks.
  • Evidence Strength
    Moderate — 20 peer-reviewed studies referenced · Community sentiment 8/10
  • Stacks Well With
    BPC-157, LL-37, Thymosin Alpha-1, Larazotide Acetate
  • Legal Status
    Research Use Only · not prescribable in US

Quick Facts

From price
$33
Type
peptide
Administration
Oral, Injection
Evidence
moderate
Studies referenced
20
Community sentiment
8/10
Stacks with
4 peptides
Regulatory
Research Use Only

Top benefits

🫃 Gut Health
9/10
🧊 Inflammation
9/10
🛡️ Immune Support
4/10
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1

Week 1–2

Reduction in systemic inflammation markers. If targeting gut, mild reduction in bloating and discomfort. Anti-inflammatory effects beginning.

2

Week 3–6

Significant improvement in inflammatory gut conditions. Reduced skin inflammation (psoriasis, eczema). Improved mucosal barrier integrity measurable.

3

Week 8+

Sustained inflammation control. Gut barrier healing. Reduced frequency and severity of autoimmune flares. Improved overall immune balance.

Common Side Effects

Injection site irritationMild headacheTransient fatigue
Tolerance: Not well-characterized — anti-inflammatory mechanism unlikely to develop tolerance
Cycling: 4-8 weeks on, 2-4 weeks off. Can be used longer for chronic inflammatory conditions.

Scientific Overview

KPV is an α-MSH-derived tripeptide retaining anti-inflammatory properties without melanotropic activity. Inhibits NF-κB nuclear translocation and reduces IL-1β, IL-6, and TNF-α. Demonstrated efficacy in IBD models by reducing mucosal inflammation and promoting epithelial barrier integrity.

Dosing

200-500 mcg oral or subq daily. Take it by mouth if you're targeting the gut specifically. Cycle for 4-8 weeks.

Reconstitution, storage, injection sites & timing

Benefit Profile

🫃 Gut Health
9/10
🧊 Inflammation
9/10
🛡️ Immune Support
4/10
✨ Skin & Hair
3/10
Medical oversight recommendedNot safe during pregnancy· 2 contraindications