peptide
KPV
moderateResearch Use OnlyOralInjection
Three-amino-acid anti-inflammatory peptide especially effective for gut inflammation. Go-to for IBD and inflammatory gut issues. Also calms systemic inflammation.
Key facts
- Classification
- KPV is an α-MSH-derived tripeptide retaining anti-inflammatory properties without melanotropic activity.
- Primary benefits
- Gut Health (9/10) · Inflammation (9/10) · Immune Support (4/10)
- Administration
- Oral, Injection
- Doses studied
- 200-500 mcg oral or subq daily. Take it by mouth if you're targeting the gut specifically. Cycle for 4-8 weeks.
- Evidence strength
- Moderate — 20 peer-reviewed studies
- Stacks well with
- BPC-157, LL-37, Thymosin Alpha-1, Larazotide Acetate
- Legal status
- Research Use Only · not prescribable in US
Quick stats
- Type
- Peptide
- Administration
- Oral, Injection
- Studies referenced
- 20
- Stacks with
- 4 peptides
- Regulatory
- Research Use Only
Scientific overview
KPV is an α-MSH-derived tripeptide retaining anti-inflammatory properties without melanotropic activity. Inhibits NF-κB nuclear translocation and reduces IL-1β, IL-6, and TNF-α. Demonstrated efficacy in IBD models by reducing mucosal inflammation and promoting epithelial barrier integrity.
Goal coverage · KPV
🫃 Gut Health9/10
🧊 Inflammation9/10
🛡️ Immune Support4/10
✨ Skin & Hair3/10
Medical oversight recommendedNot safe during pregnancy· 2 contraindications