🫃 Best Peptides for Gut Health

A healing compound from human gastric juice. The most extensively studied repair peptide in animal models, with strong preclinical data for tissue repair, gut restoration, and anti-inflammatory effects. Human clinical data remains limited.

Three-amino-acid anti-inflammatory peptide especially effective for gut inflammation. Go-to for IBD and inflammatory gut issues. Also calms systemic inflammation.

Oral-stable BPC-157 formulation using arginine salt for bioavailability. Delivers peptide directly to the GI tract for localized gut healing without injections.

Tightens seals between gut lining cells, directly addressing leaky gut. Developed for celiac disease but useful for gut barrier problems broadly.

Pre-mixed BPC-157 + TB-500 healing combo. Combines targeted tissue repair with systemic healing, amplifying anti-inflammatory and regenerative effects.

Neuropeptide with powerful anti-inflammatory properties. Widely used in mold illness (CIRS) protocols. Regulates gut and lung inflammation, supports immune balance.

Dual GLP-1/glucagon weight loss peptide from Boehringer Ingelheim. The glucagon component adds liver fat reduction, promising for fatty liver disease alongside obesity.

Your body's natural antibiotic peptide. Fights bacteria, viruses, and fungi, breaks up biofilms, and supports wound healing while modulating immune response.

Active ingredient in Ozempic/Wegovy. Mimics GLP-1 to signal fullness and slow gastric emptying. STEP trials showed 14.9% weight loss at 68 weeks.

Dual GLP-1/glucagon receptor drug from Innovent Biologics. Strong weight loss and metabolic results. Already approved in China for obesity.

A naturally occurring copper peptide your body already makes. Drives skin rejuvenation, wound healing, and anti-aging by boosting collagen and activating anti-aging genes.

28-amino-acid immune peptide from thymus tissue. Strengthens T-cell maturation, boosts natural killer cells, and balances immune response. Tested in 30+ trials, approved in 35+ countries for hepatitis, HIV support, and infections. No serious side effects.

Semi-synthetic polysaccharide (not a peptide) with anti-inflammatory and cartilage-protecting properties. FDA-approved for interstitial cystitis. Widely used for joint health.

Active ingredient in Mounjaro/Zepbound. Dual GLP-1/GIP agonist — more effective than semaglutide. SURMOUNT-1 showed up to 22.5% weight loss at 72 weeks.

Next-gen triple agonist from Eli Lilly hitting GLP-1, GIP, and glucagon receptors. Phase 2 showed 24.2% weight loss at 48 weeks — highest of any incretin therapy. At low doses, optimizes metabolism without major weight loss.

First-gen GLP-1 drug (Saxenda/Victoza). Less potent than semaglutide but has years of clinical data and established safety profile. Requires daily injection.

Semaglutide + cagrilintide combo in Phase 3 trials. Strongest weight loss data of any injectable to date, surpassing semaglutide alone through dual appetite/satiety targeting.

First oral non-peptide GLP-1 agonist in late-stage trials. A daily pill alternative to injectable GLP-1s with promising early weight loss data.