Skip to content

Tesofensine

Phase 2/3 Clinical Trials
capsuleOral

Originally for Parkinson's/Alzheimer's, found to cause major weight loss. Boosts serotonin, dopamine, and norepinephrine simultaneously, crushing appetite and revving metabolism.

Key Facts

  • Classification
    Tesofensine is a triple monoamine reuptake inhibitor (5-HT, NE, DA).
  • Primary Benefits
    Fat Loss (7/10) · Brain & Cognition (4/10) · Mood & Anxiety (3/10)
  • Administration
    Oral
  • Typical Dose
    0.25-0.5 mg by mouth daily. Start at the lower dose. Cycle for 12-24 weeks.
  • Evidence Strength
    Emerging — 20 peer-reviewed studies referenced · Community sentiment 9/10
  • Stacks Well With
    Semaglutide, 5-Amino-1MQ
  • Legal Status
    Phase 2/3 Clinical Trials · not prescribable in US

Quick Facts

From price
$70
Type
capsule
Administration
Oral
Evidence
emerging
Studies referenced
20
Community sentiment
9/10
Stacks with
2 peptides
Regulatory
Phase 2/3 Clinical Trials

Top benefits

🔥 Fat Loss
7/10
🧠 Brain & Cognition
4/10
😌 Mood & Anxiety
3/10
View PricingCompare
1

Week 1–2

Appetite suppression noticeable within days. Increased energy and motivation. Possible mild stimulant effects — heart rate may increase slightly.

2

Week 3–6

Significant weight loss (triple monoamine reuptake inhibition driving appetite suppression and thermogenesis). Improved mood and motivation from dopamine effects.

3

Week 8+

Substantial weight loss (10%+ body weight in trials). Sustained appetite control. Cardiovascular parameters need ongoing monitoring.

Common Side Effects

Increased heart rateElevated blood pressureDry mouthInsomniaConstipationNauseaAnxiety/restlessness
Tolerance: Possible mild tolerance to appetite suppression after 12-16 weeks
Cycling: Still in clinical trials. 12-24 week courses with cardiovascular monitoring. Requires medical supervision.

Scientific Overview

Tesofensine is a triple monoamine reuptake inhibitor (5-HT, NE, DA). Phase 2 obesity trials showed 4.5-10.6% weight loss over 24 weeks via central appetite suppression and thermogenesis. Requires cardiovascular monitoring due to modest HR and BP increases.

Dosing

0.25-0.5 mg by mouth daily. Start at the lower dose. Cycle for 12-24 weeks.

Reconstitution, storage, injection sites & timing

Benefit Profile

🔥 Fat Loss
7/10
🧠 Brain & Cognition
4/10
😌 Mood & Anxiety
3/10
Medical oversight requiredNot safe during pregnancy· 7 contraindications