🔥 Best Peptides for Fat Loss

Active ingredient in Ozempic/Wegovy. Mimics GLP-1 to signal fullness and slow gastric emptying. STEP trials showed 14.9% weight loss at 68 weeks.

Active ingredient in Mounjaro/Zepbound. Dual GLP-1/GIP agonist — more effective than semaglutide. SURMOUNT-1 showed up to 22.5% weight loss at 72 weeks.

Next-gen triple agonist from Eli Lilly hitting GLP-1, GIP, and glucagon receptors. Phase 2 showed 24.2% weight loss at 48 weeks — highest of any incretin therapy. At low doses, optimizes metabolism without major weight loss.

Semaglutide + cagrilintide combo in Phase 3 trials. Strongest weight loss data of any injectable to date, surpassing semaglutide alone through dual appetite/satiety targeting.

Dual GLP-1/glucagon weight loss peptide from Boehringer Ingelheim. The glucagon component adds liver fat reduction, promising for fatty liver disease alongside obesity.

Dual GLP-1/glucagon receptor drug from Innovent Biologics. Strong weight loss and metabolic results. Already approved in China for obesity.

First oral non-peptide GLP-1 agonist in late-stage trials. A daily pill alternative to injectable GLP-1s with promising early weight loss data.

FDA-approved GH booster for reducing visceral belly fat in HIV-associated lipodystrophy. Trials showed ~15-18% visceral fat reduction. Overall weight loss is modest vs GLP-1 agonists.

Mitochondrial DNA-encoded peptide that activates AMPK, improving insulin sensitivity, fat burning, and mimicking exercise at the cellular level. Stacks well with SS-31 and NAD+.

First-gen GLP-1 drug (Saxenda/Victoza). Less potent than semaglutide but has years of clinical data and established safety profile. Requires daily injection.

Long-lasting growth hormone booster. The DAC modification keeps it active for days, producing steady GH elevation for muscle growth, fat loss, and recovery.

Pre-mixed Ipamorelin + CJC-1295 combo. Works through complementary pathways for strong, clean GH release. The gold standard starter stack for GH optimization.

Originally for Parkinson's/Alzheimer's, found to cause major weight loss. Boosts serotonin, dopamine, and norepinephrine simultaneously, crushing appetite and revving metabolism.

Exercise mimetic that activates endurance pathways, improves mitochondrial function, increases fat burning, and boosts muscle endurance — without actual exercise.

Shorter-acting GH booster that releases growth hormone in natural pulses. Clears faster without DAC, so it's usually paired with another GH peptide for stronger effect.

One of the cleanest GH boosters. Stimulates growth hormone release without affecting cortisol or prolactin, meaning fewer side effects than other GH peptides.

The fat-burning fragment of growth hormone (amino acids 176-191). Promotes fat breakdown without muscle or blood sugar effects. Note: a Phase IIb trial failed to show significant weight loss vs placebo.

One of the most prescribed GH peptides. Copies the first 29 amino acids of natural GHRH, triggering physiological GH pulses from the pituitary.

Stronger GH release than GHRP-6, with more moderate appetite increase. Raises both GH and IGF-1, though it can slightly bump cortisol and prolactin.

The most potent GH-releasing peptide, producing the biggest growth hormone spike in its class. Also has cardioprotective benefits. Tolerance builds faster than other options.

Orally active ghrelin receptor agonist (not a peptide). Boosts growth hormone and IGF-1. Known for improving deep sleep, increasing appetite, and gradually improving body composition.

Small molecule blocking NNMT, an enzyme that slows metabolism. Increases NAD+ production and energy expenditure. Promotes fat loss and may fix metabolic issues.

Blocks myostatin — the protein that caps muscle growth. May allow muscles to grow beyond typical limits, though human data is very limited.

The fat-burning fragment of HGH (amino acids 176-191). Targets fat breakdown without growth or blood sugar effects. Very similar to AOD-9604.

Primes skin to produce more melanin, reducing UV exposure needed to tan. Also suppresses appetite and boosts libido. Some UV still required to trigger darkening.

Modified IGF-1 with extended half-life. Can create new muscle cells (not just enlarge existing ones), making it one of the most potent muscle-building peptides.

SARM offering ~66% of testosterone's muscle-building effects with only ~27% of its androgenic side effects. A milder lean mass builder.

DISCONTINUED. Experimental peptide that cuts blood supply to fat cells. Terminated due to unacceptable kidney toxicity in primates. No human trials conducted.

GH booster that significantly increases appetite by mimicking ghrelin. Good for bulking or anyone who struggles to eat enough.

Engineered to target inner mitochondrial membrane via cardiolipin binding. Stabilizes cristae, improves ATP production, and reduces oxidative stress. FDA-approved for Barth syndrome (as Forzinity) — the first FDA-approved mitochondria-targeted therapy.

Critical molecule for cellular energy and DNA repair. Levels may drop ~50% by middle age. Activates sirtuin longevity genes and powers PARP DNA repair enzymes. Injectable form bypasses oral absorption issues.

10x more potent IGF-1 variant with very short half-life. Inject directly into target muscle for localized growth before it clears.

Long-lasting growth factor released when muscles are damaged during exercise. Activates dormant muscle stem cells for repair and growth. Best used post-training.