🔥 Best Peptides for Fat Loss
Metabolic peptides target fat loss through appetite regulation, increased energy expenditure, and preferential visceral fat reduction. GLP-1 receptor agonists, growth hormone secretagogues, and mitochondrial enhancers each offer distinct mechanisms for improving body composition. Several compounds in this category have robust clinical trial data and FDA approval.
Semaglutide
strongGLP-1 drug (Ozempic/Wegovy) that suppresses appetite and burns fat.
Tirzepatide
strongDual GLP-1/GIP drug (Mounjaro/Zepbound). Strongest weight loss peptide available.
Retatrutide
moderateTriple-action weight loss drug hitting GLP-1, GIP, and glucagon receptors.
Survodutide
emergingDual GLP-1/glucagon weight loss peptide from Boehringer Ingelheim.
Orforglipron
emergingFirst oral non-peptide GLP-1 agonist in late-stage trials.
Tesamorelin
strongFDA-approved GH booster that specifically reduces visceral belly fat.
Liraglutide
strongFirst-gen GLP-1 drug (Saxenda/Victoza). Effective but weaker than semaglutide.
CJC-1295 with DAC
moderateLong-acting growth hormone booster that stays active for days.
Ipamorelin/CJC-1295 Blend
moderatePre-mixed combo of Ipamorelin + CJC-1295 for convenient GH boosting.
Tesofensine
emergingPotent weight loss drug originally developed for neurological conditions.
SLU-PP-332
anecdotalExercise mimetic that activates endurance pathways without working out.
CJC-1295 (no DAC) / Mod GRF 1-29
moderateGrowth hormone releaser that mimics natural pulsatile GH patterns.
Ipamorelin
moderateClean GH booster with minimal side effects. Often paired with CJC-1295.
Sermorelin
strongOne of the most commonly prescribed GH peptides. Natural 29-amino-acid GH releaser.
MK-677 (Ibutamoren)
moderateOral GH booster (not a peptide). Raises growth hormone and IGF-1 levels.
5-Amino-1MQ
emergingBlocks the NNMT enzyme to speed up metabolism and burn more fat. Evidence is almost entirely preclinical.
Follistatin 344
emergingBlocks myostatin to remove the genetic cap on muscle growth.
HGH Fragment 176-191
emergingThe fat-burning slice of HGH without growth or blood sugar side effects. Similar to AOD-9604.
Melanotan II
moderateDarkens skin with less UV exposure. Also affects appetite and libido.
AC-262,536
anecdotalSARM with 66% of testosterone's muscle-building power and fewer side effects.
Adipotide (FTPP)
anecdotalDISCONTINUED: Experimental peptide that cuts blood supply to fat cells. Terminated due to kidney toxicity.
SS-31 (Elamipretide)
moderateTargets and repairs damaged mitochondria. Boosts cellular energy production.
Essential cellular energy molecule. Levels drop ~50% by middle age.
IGF-1 DES (1-3)
emerging10x more potent IGF-1 variant with very short duration. Targets local muscle.
PEG-MGF (Mechano Growth Factor)
emergingLong-lasting muscle growth factor released after exercise-induced damage.