molecule
NAD+ (Nicotinamide Adenine Dinucleotide)
moderateResearch Use OnlyInjection
Critical molecule for cellular energy and DNA repair. Levels may drop ~50% by middle age. Activates sirtuin longevity genes and powers PARP DNA repair enzymes. Injectable form bypasses oral absorption issues.
Key facts
- Classification
- NAD+ is a critical coenzyme in redox reactions and substrate for sirtuins, PARPs, and CD38.
- Primary benefits
- Longevity (10/10) · Brain & Cognition (7/10) · Sleep (5/10)
- Administration
- Injection
- Doses studied
- 25-50 mg subq, 3 times a week on an empty stomach. Start at 25 mg. Can be mixed in the same syringe with SS-31. Flushing (warm, red skin) is common if you go above 100 mg.
- Evidence strength
- Moderate — 20 peer-reviewed studies
- Stacks well with
- SS-31, MOTS-c, Epithalon, Semax
- Legal status
- Research Use Only · not prescribable in US
Quick stats
- Type
- Molecule
- Administration
- Injection
- Studies referenced
- 20
- Stacks with
- 7 peptides
- Regulatory
- Research Use Only
Scientific overview
NAD+ is a critical coenzyme in redox reactions and substrate for sirtuins, PARPs, and CD38. Intracellular levels may decline substantially between ages 40-60. Exogenous supplementation bypasses the NAMPT rate-limiting step, improving mitochondrial membrane potential, energy production, and DNA repair capacity.
Goal coverage · NAD+ (Nicotinamide Adenine Dinucleotide)
⏳ Longevity10/10
🧠 Brain & Cognition7/10
😴 Sleep5/10
💪 Muscle Growth4/10
🔥 Fat Loss3/10
🧊 Inflammation3/10
Medical oversight strongly recommendedNot safe during pregnancy· 3 contraindications