peptide
MOTS-c
emergingResearch Use OnlyInjection
Mitochondrial DNA-encoded peptide that activates AMPK, improving insulin sensitivity, fat burning, and mimicking exercise at the cellular level. Stacks well with SS-31 and NAD+.
Key facts
- Classification
- MOTS-c is a 16-amino acid mitochondrial-derived peptide.
- Primary benefits
- Fat Loss (8/10) · Longevity (7/10) · Muscle Growth (4/10)
- Administration
- Injection
- Doses studied
- 5-10 mg subq per week, split into 2-3 doses. Best taken on an empty stomach, 30-60 minutes before exercise. Start at 5 mg/week.
- Evidence strength
- Emerging — 20 peer-reviewed studies
- Stacks well with
- SS-31, NAD+, Epithalon, Retatrutide
- Legal status
- Research Use Only · not prescribable in US
Quick stats
- Type
- Peptide
- Administration
- Injection
- Studies referenced
- 20
- Stacks with
- 5 peptides
- Regulatory
- Research Use Only
Scientific overview
MOTS-c is a 16-amino acid mitochondrial-derived peptide. Activates AMPK, enhances insulin-independent glucose uptake, and promotes fatty acid oxidation. Translocates to the nucleus under metabolic stress to regulate antioxidant response genes. Exercise-induced increases suggest it mediates some exercise benefits.
Goal coverage · MOTS-c
🔥 Fat Loss8/10
⏳ Longevity7/10
💪 Muscle Growth4/10
🧊 Inflammation4/10
Medical oversight recommendedNot safe during pregnancy· 3 contraindications