capsule
MK-677 (Ibutamoren)
moderateResearch Use OnlyOral
Orally active ghrelin receptor agonist (not a peptide). Boosts growth hormone and IGF-1. Known for improving deep sleep, increasing appetite, and gradually improving body composition.
Key facts
- Classification
- Ibutamoren (MK-677) is an orally active non-peptide GHS mimicking ghrelin at GHSR-1a.
- Primary benefits
- Sleep (8/10) · Muscle Growth (7/10) · Fat Loss (5/10)
- Administration
- Oral
- Doses studied
- 10-25 mg by mouth daily, ideally before bed. Can be used long-term, but keep an eye on bloodwork.
- Evidence strength
- Moderate — 20 peer-reviewed studies
- Stacks well with
- CJC-1295 with DAC, Ipamorelin, Sermorelin, DSIP
- Legal status
- Research Use Only · not prescribable in US · WADA prohibited
Quick stats
- Type
- Capsule
- Administration
- Oral
- Studies referenced
- 20
- Stacks with
- 5 peptides
- Regulatory
- Research Use Only
Scientific overview
Ibutamoren (MK-677) is an orally active non-peptide GHS mimicking ghrelin at GHSR-1a. Produces sustained 24-hour GH elevation and 40-60% IGF-1 increase. Clinical trials in elderly showed improved lean mass, bone density, and sleep architecture. Preserves pulsatile GH secretion. Side effects include appetite stimulation and transient insulin resistance.
Goal coverage · MK-677 (Ibutamoren)
😴 Sleep8/10
💪 Muscle Growth7/10
🔥 Fat Loss5/10
⏳ Longevity4/10
✨ Skin & Hair4/10
🩹 Injury Healing4/10
Medical oversight strongly recommendedNot safe during pregnancy· 5 contraindications