peptide
PE-22-28
anecdotalResearch Use OnlyIntranasalInjection
Rapid-acting antidepressant peptide. Inhibits TREK-1 potassium channels, boosting neuronal excitability and triggering fast BDNF upregulation. Mouse studies show antidepressant effects within days.
Key facts
- Classification
- Peptide — Fast-acting antidepressant and cognitive enhancer. Blocks TREK-1 channels.
- Primary benefits
- Brain & Cognition (8/10) · Mood & Anxiety (7/10)
- Administration
- Intranasal, Injection
- Doses studied
- 200-500 mcg as a nasal spray or subq daily. Cycle 4 weeks on, then take a break.
- Evidence strength
- Anecdotal — 21 peer-reviewed studies
- Stacks well with
- Semax, Selank
- Legal status
- Research Use Only · not prescribable in US
Quick stats
- Type
- Peptide
- Administration
- Intranasal, Injection
- Studies referenced
- 21
- Stacks with
- 2 peptides
- Regulatory
- Research Use Only
Goal coverage · PE-22-28
🧠 Brain & Cognition8/10
😌 Mood & Anxiety7/10