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PE-22-28

Research Use Only
peptideIntranasalInjection

Rapid-acting antidepressant peptide. Inhibits TREK-1 potassium channels, boosting neuronal excitability and triggering fast BDNF upregulation. Mouse studies show antidepressant effects within days.

Key Facts

  • Classification
    Peptide — Fast-acting antidepressant and cognitive enhancer. Blocks TREK-1 channels.
  • Primary Benefits
    Brain & Cognition (8/10) · Mood & Anxiety (7/10)
  • Administration
    Intranasal, Injection
  • Typical Dose
    200-500 mcg as a nasal spray or subq daily. Cycle 4 weeks on, then take a break.
  • Evidence Strength
    Anecdotal — 21 peer-reviewed studies referenced · Community sentiment 9/10
  • Stacks Well With
    Semax, Selank
  • Legal Status
    Research Use Only · not prescribable in US

Quick Facts

From price
$45
Type
peptide
Administration
Intranasal, Injection
Evidence
anecdotal
Studies referenced
21
Community sentiment
9/10
Stacks with
2 peptides
Regulatory
Research Use Only

Top benefits

🧠 Brain & Cognition
8/10
😌 Mood & Anxiety
7/10
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Dosing

200-500 mcg as a nasal spray or subq daily. Cycle 4 weeks on, then take a break.

Benefit Profile

🧠 Brain & Cognition
8/10
😌 Mood & Anxiety
7/10