Selank
Russian anxiolytic peptide working on GABA, serotonin, and enkephalin systems. Eases anxiety without sedation or dependence risk. Also boosts immunity. Decades of clinical use.
Key Facts
- ClassificationSelank is a synthetic tuftsin analog with added Pro-Gly-Pro for stability.
- Primary BenefitsMood & Anxiety (9/10) · Brain & Cognition (7/10) · Immune Support (5/10)
- AdministrationIntranasal, Injection
- Typical Dose250-500 mcg subq or nasal spray, 3 times a week or as needed. No tolerance builds up, so no cycling needed. Can be mixed in the same syringe with Semax, SS-31, or NAD+.
- Evidence StrengthModerate — 20 peer-reviewed studies referenced · Community sentiment 10/10
- Stacks Well WithSemax, Dihexa, SS-31, NAD+
- Legal StatusResearch Use Only · not prescribable in US
Quick Facts
- From price
- $30
- Type
- peptide
- Administration
- Intranasal, Injection
- Evidence
- moderate
- Studies referenced
- 20
- Community sentiment
- 10/10
- Stacks with
- 6 peptides
- Regulatory
- Research Use Only
Top benefits
Week 1–2
Anxiolytic effects noticeable within hours to days. Improved mental clarity and reduced mental chatter. Better stress tolerance. Subtle mood elevation.
Week 3–6
Sustained anxiety reduction comparable to low-dose benzodiazepines without sedation. Improved cognitive flexibility. Better social comfort. Enhanced focus.
Week 8+
Stabilized mood and anxiety baseline. Improved immune markers. Cognitive benefits may plateau — cycle off and restart for renewed effects.
Common Side Effects
Scientific Overview
Selank is a synthetic tuftsin analog with added Pro-Gly-Pro for stability. Modulates GABAergic, serotonergic, and dopaminergic neurotransmission with benzodiazepine-comparable anxiolysis without sedation or dependence. Influences 36 genes including BDNF upregulation. Approved in Russia for GAD.
Dosing
250-500 mcg subq or nasal spray, 3 times a week or as needed. No tolerance builds up, so no cycling needed. Can be mixed in the same syringe with Semax, SS-31, or NAD+.
Reconstitution, storage, injection sites & timing
Benefit Profile
| Vendor | Variant | Price | |
|---|---|---|---|
| Limitless Biotech | Nasal 5mg | $44.99 | Code: PSTACK10Buy |
| Skye Peptides | 5mg | $34.99 | |
| Skye Peptides | Nasal 5mg | $44.99 | |
| Amino Asylum ⚠ Reported federal raid in 2025 | 5mg | $29.99BEST | |
| Peptide Sciences ✕ Announced voluntary shutdown — stock availability may be limited or unavailable. Pricing data may be outdated. | 5mg | $42.00 | Out of stock |
Stacks Well With
Semax
Brain-boosting peptide that increases BDNF by ~1.4x at the protein level and up to 3x at mRNA level in animal studies. Promotes neurogenesis, improves cerebral blood flow. Used clinically in Russia for stroke recovery and cognitive decline.
Dihexa
Brain peptide originally claimed to be 10 million times more potent than BDNF for forming connections. However, the foundational paper was retracted in April 2025 after confirmed data fabrication. A clinical trial also failed all endpoints. Evidence base is now significantly weakened.
SS-31 (Elamipretide)
Engineered to target inner mitochondrial membrane via cardiolipin binding. Stabilizes cristae, improves ATP production, and reduces oxidative stress. FDA-approved for Barth syndrome (as Forzinity) — the first FDA-approved mitochondria-targeted therapy.
NAD+ (Nicotinamide Adenine Dinucleotide)
Critical molecule for cellular energy and DNA repair. Levels may drop ~50% by middle age. Activates sirtuin longevity genes and powers PARP DNA repair enzymes. Injectable form bypasses oral absorption issues.
Thymosin Alpha-1
28-amino-acid immune peptide from thymus tissue. Strengthens T-cell maturation, boosts natural killer cells, and balances immune response. Tested in 30+ trials, approved in 35+ countries for hepatitis, HIV support, and infections. No serious side effects.
N-Acetyl Selank Amidate
Enhanced Selank with better stability and bioavailability. Delivers stronger anxiolytic and immune-boosting effects than regular Selank.
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NA-Semax Amidate6/10Enhanced version of Semax with better absorption and stronger brain effects.
9-Me-BC (9-Methyl-β-carboline)6/10Unique dopamine-enhancing brain booster that promotes nerve growth.