TB-500 (Thymosin Beta-4)
Synthetic Thymosin Beta-4, a protein that drives cell migration and tissue repair. Promotes angiogenesis, reduces inflammation, and supports tissue remodeling body-wide. Popular for injury recovery.
Key Facts
- ClassificationThymosin Beta-4 is a 43-amino acid polypeptide that sequesters G-actin monomers, regulating actin polymerization for cell migration and tissue remodeling.
- Primary BenefitsInjury Healing (9/10) · Inflammation (8/10) · Muscle Growth (5/10)
- AdministrationInjection
- Typical DoseLoading phase: 2-5 mg subq twice a week for 4 weeks. Then drop to 2 mg twice a week for maintenance.
- Evidence StrengthModerate — 20 peer-reviewed studies referenced · Community sentiment 9/10
- Stacks Well WithBPC-157, GHK-Cu, SS-31, NAD+
- Legal StatusResearch Use Only · not prescribable in US · WADA prohibited
Quick Facts
- From price
- $35
- Type
- peptide
- Administration
- Injection
- Evidence
- moderate
- Studies referenced
- 20
- Community sentiment
- 9/10
- Stacks with
- 5 peptides
- Regulatory
- Research Use Only
Top benefits
Week 1–2
Subtle reduction in systemic inflammation. Injury sites may feel slightly less stiff. Loading dose period — effects are accumulating.
Week 3–6
Improved flexibility and range of motion at injury sites. Visible wound healing acceleration. Reduced swelling in chronic injuries.
Week 8+
Significant tissue remodeling and repair. New blood vessel formation in previously poorly-vascularized injuries. Sustained anti-inflammatory benefits.
Common Side Effects
Scientific Overview
Thymosin Beta-4 is a 43-amino acid polypeptide that sequesters G-actin monomers, regulating actin polymerization for cell migration and tissue remodeling. Promotes angiogenesis through VEGF upregulation. Anti-inflammatory properties stem from NF-κB inhibition and reduced pro-inflammatory cytokines (IL-1β, TNF-α). Crosses the blood-brain barrier with demonstrated neuroprotective properties.
Dosing
Loading phase: 2-5 mg subq twice a week for 4 weeks. Then drop to 2 mg twice a week for maintenance.
Reconstitution, storage, injection sites & timing
Benefit Profile
| Vendor | Variant | Price | |
|---|---|---|---|
| Limitless Biotech | 5mg | $42.99 | Code: PSTACK10Buy |
| Skye Peptides | 5mg | $42.99 | |
| Skye Peptides | 10mg | $72.99 | |
| Swiss Chems ⚠ FDA warning letter received late 2024 | 5mg | $39.95 | |
| Amino Asylum ⚠ Reported federal raid in 2025 | 5mg | $34.99BEST | |
| Peptide Sciences ✕ Announced voluntary shutdown — stock availability may be limited or unavailable. Pricing data may be outdated. | 5mg | $45.00 | Out of stock |
Stacks Well With
BPC-157
A healing compound from human gastric juice. The most extensively studied repair peptide in animal models, with strong preclinical data for tissue repair, gut restoration, and anti-inflammatory effects. Human clinical data remains limited.
GHK-Cu (Copper Peptide)
A naturally occurring copper peptide your body already makes. Drives skin rejuvenation, wound healing, and anti-aging by boosting collagen and activating anti-aging genes.
SS-31 (Elamipretide)
Engineered to target inner mitochondrial membrane via cardiolipin binding. Stabilizes cristae, improves ATP production, and reduces oxidative stress. FDA-approved for Barth syndrome (as Forzinity) — the first FDA-approved mitochondria-targeted therapy.
NAD+ (Nicotinamide Adenine Dinucleotide)
Critical molecule for cellular energy and DNA repair. Levels may drop ~50% by middle age. Activates sirtuin longevity genes and powers PARP DNA repair enzymes. Injectable form bypasses oral absorption issues.
KPV
Three-amino-acid anti-inflammatory peptide especially effective for gut inflammation. Go-to for IBD and inflammatory gut issues. Also calms systemic inflammation.
Compare
BPC-157 and TB-500 are the two most popular healing peptides, often discussed together. Both promote tissue repair, but through distinct mechanisms. BPC-157 is derived from a protective protein found in gastric juice, while TB-500 is a synthetic fragment of thymosin beta-4, a naturally occurring protein involved in cell migration and wound healing.
TB-500 vs GHK-CuTB-500 and GHK-Cu are both tissue repair peptides, but they serve different roles in the healing process. TB-500 focuses on recruiting repair cells and building new blood vessels, while GHK-Cu strengthens tissue quality through collagen remodeling and gene expression changes.
Thymosin Alpha-1 vs Thymosin Beta-4Despite sharing the "thymosin" name, Thymosin Alpha-1 (TA-1) and Thymosin Beta-4 (TB-4/TB-500) serve very different functions. TA-1 is an immune modulator, while TB-4 is a tissue repair peptide. They were both originally isolated from the thymus gland, but their biological roles are distinct.
Related 🩹 Injury Healing Peptides
Other peptides strong in injury healing
Pre-mixed BPC-157 + TB-500 combo for maximum healing and recovery.
Pentosan Polysulfate (PPS)7/10Anti-inflammatory that protects cartilage and treats joint degeneration.
ARA-290 (Cibinitide)7/10EPO-derived repair peptide that reduces nerve pain without affecting blood cells.
Cerebrolysin6/10Brain-repair blend with natural nerve growth factors. Used in stroke recovery.
PEG-MGF (Mechano Growth Factor)6/10Long-lasting muscle growth factor released after exercise-induced damage.
BPC-157 Arginine Salt (Oral Stable Form)6/10Oral-stable BPC-157 formulation for convenient gut-targeted healing.