Best Peptide Stack for Fat Loss
Fat loss peptides attack body composition from multiple angles: GLP-1 agonists crush appetite, GH secretagogues mobilize fat, and mitochondrial enhancers boost metabolic rate. Stacking accelerates results while preserving muscle.
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Fat Loss Subcategories
Appetite Control
Satiety signaling, craving reduction
View best peptides →Metabolic Rate
Basal metabolism, thermogenesis, energy expenditure
View best peptides →Visceral Fat
Targeting deep abdominal fat stores
View best peptides →Body Recomposition
Simultaneous fat loss and muscle preservation
View best peptides →Top Peptides for Fat Loss
Semaglutide
strongActive ingredient in Ozempic/Wegovy. Mimics GLP-1 to signal fullness and slow gastric emptying. STEP trials showed 14.9% weight loss at 68 weeks.
Tirzepatide
strongActive ingredient in Mounjaro/Zepbound. Dual GLP-1/GIP agonist — more effective than semaglutide. SURMOUNT-1 showed up to 22.5% weight loss at 72 weeks.
Retatrutide
moderateNext-gen triple agonist from Eli Lilly hitting GLP-1, GIP, and glucagon receptors. Phase 2 showed 24.2% weight loss at 48 weeks — highest of any incretin therapy. At low doses, optimizes metabolism without major weight loss.
CagriSema
emergingSemaglutide + cagrilintide combo in Phase 3 trials. Strongest weight loss data of any injectable to date, surpassing semaglutide alone through dual appetite/satiety targeting.
Survodutide
emergingDual GLP-1/glucagon weight loss peptide from Boehringer Ingelheim. The glucagon component adds liver fat reduction, promising for fatty liver disease alongside obesity.
Mazdutide
emergingDual GLP-1/glucagon receptor drug from Innovent Biologics. Strong weight loss and metabolic results. Already approved in China for obesity.
Orforglipron
emergingFirst oral non-peptide GLP-1 agonist in late-stage trials. A daily pill alternative to injectable GLP-1s with promising early weight loss data.
Tesamorelin
strongFDA-approved GH booster for reducing visceral belly fat in HIV-associated lipodystrophy. Trials showed ~15-18% visceral fat reduction. Overall weight loss is modest vs GLP-1 agonists.
MOTS-c
emergingMitochondrial DNA-encoded peptide that activates AMPK, improving insulin sensitivity, fat burning, and mimicking exercise at the cellular level. Stacks well with SS-31 and NAD+.
Proven Synergy Stacks for Fat Loss
Mitochondrial-axis overlap. SS-31 binds cardiolipin to stabilize inner-membrane structure; NAD+ is the redox substrate for sirtuin and electron-transport flux. Together they target the same organelle through complementary nodes (structure + cofactor pool).
GHRH × GHRP convergence on the somatotroph. CJC-1295 (GHRH analog) primes the pituitary; ipamorelin (selective GHRP) triggers GH release without ACTH or prolactin elevation.
AMPK convergence at different tiers. Retatrutide is a triple agonist at GLP-1, GIP, and glucagon receptors (Phase 2 NEJM 2023, N=338); MOTS-c is a mitochondrial-derived peptide that upregulates AMPK and GLUT4 translocation in muscle. Hormone-axis × intracellular-energy-sensor pair.
GLP-1/GIP/glucagon triple-receptor signaling combined with NAD+ as substrate for sirtuin-driven lipid oxidation gene expression. Hormonal-axis × cofactor-pool pair.
Triple-incretin receptor signaling combined with mitochondrial-membrane stabilization. Hormonal-axis × organelle-structure pair — Phase 3 retatrutide trials ongoing; SS-31 Phase 3 MMPOWER-3 missed primary endpoint.
GH-axis pairing. Tesamorelin is an FDA-approved GHRH analog (HIV-associated lipodystrophy indication); AOD-9604 is a GH C-terminal fragment with lipolytic activity in preclinical models (Phase IIb missed obesity endpoint).
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