Best Peptide Stack for Fat Loss
Fat loss peptides attack body composition from multiple angles: GLP-1 agonists crush appetite, GH secretagogues mobilize fat, and mitochondrial enhancers boost metabolic rate. Stacking accelerates results while preserving muscle.
Build Your Fat Loss StackFat Loss Subcategories
Appetite Control
Satiety signaling, craving reduction
View best peptides →Metabolic Rate
Basal metabolism, thermogenesis, energy expenditure
View best peptides →Visceral Fat
Targeting deep abdominal fat stores
View best peptides →Body Recomposition
Simultaneous fat loss and muscle preservation
View best peptides →Top Peptides for Fat Loss
Semaglutide
Active ingredient in Ozempic/Wegovy. Mimics GLP-1 to signal fullness and slow gastric emptying. STEP trials showed 14.9% weight loss at 68 weeks.
Tirzepatide
Active ingredient in Mounjaro/Zepbound. Dual GLP-1/GIP agonist — more effective than semaglutide. SURMOUNT-1 showed up to 22.5% weight loss at 72 weeks.
Retatrutide
Next-gen triple agonist from Eli Lilly hitting GLP-1, GIP, and glucagon receptors. Phase 2 showed 24.2% weight loss at 48 weeks — highest of any incretin therapy. At low doses, optimizes metabolism without major weight loss.
CagriSema
Semaglutide + cagrilintide combo in Phase 3 trials. Strongest weight loss data of any injectable to date, surpassing semaglutide alone through dual appetite/satiety targeting.
Survodutide
Dual GLP-1/glucagon weight loss peptide from Boehringer Ingelheim. The glucagon component adds liver fat reduction, promising for fatty liver disease alongside obesity.
Mazdutide
Dual GLP-1/glucagon receptor drug from Innovent Biologics. Strong weight loss and metabolic results. Already approved in China for obesity.
Orforglipron
First oral non-peptide GLP-1 agonist in late-stage trials. A daily pill alternative to injectable GLP-1s with promising early weight loss data.
Tesamorelin
FDA-approved GH booster for reducing visceral belly fat in HIV-associated lipodystrophy. Trials showed ~15-18% visceral fat reduction. Overall weight loss is modest vs GLP-1 agonists.
MOTS-c
Mitochondrial DNA-encoded peptide that activates AMPK, improving insulin sensitivity, fat burning, and mimicking exercise at the cellular level. Stacks well with SS-31 and NAD+.
Proven Synergy Stacks for Fat Loss
SS-31 repairs your cells' power plants (mitochondria), and NAD+ is the premium fuel. Together: a tuned-up engine running on premium fuel.
Gold standard GH stack. CJC-1295 primes pituitary cells, Ipamorelin triggers clean GH release without spiking cortisol.
Different metabolic angles: Retatrutide via 3 hormone receptors, MOTS-c via AMPK switch inside cells.
Retatrutide sends metabolic signals, NAD+ provides fuel to act on them.
Retatrutide optimizes metabolism at hormone level, SS-31 at cellular level.
Tesamorelin (FDA-approved) reduces belly fat via GH, AOD-9604 tells fat cells to release stored fat.
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